An abnormal gene on the X chromosome from each parent would be required, since a female has two X chromosomes. The father, who has one X and one Y chromosome, produces sperm which could contain either an X or a Y chromosome. Queen Victoria with her husband and nine children in By comparison to the X chromosome, the much smaller Y chromosome has only about 26 genes and gene families.
This is why it is rarer to find women with hemophilia, since they would have to have both X chromosomes containing mutated copies of the gene to have the disease manifest. How do you get hemophilia? Are all of your chromosomes organized in homologous pairs?
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Creasy and Resnik's Maternal-Fetal Medicine: After an injury, blood clots protect the body by sealing off damaged blood vessels and preventing excessive blood loss.
The altered or missing protein cannot participate effectively in the blood clotting process.
Click here for more information on carriers and women with hemophilia. The mutations that cause severe hemophilia almost completely eliminate the activity of coagulation factor VIII or coagulation factor IX.
Dominant inheritance occurs when an abnormal gene from one parent causes disease, even though the matching gene from the other parent is normal. This prevents mutant Y chromosome genes from being eliminated from male genetic lines except by inactivation or deletion.
Review provided by VeriMed Healthcare Network.